Targeting An Aflatoxin-Safe World

U.S. research is targeting the dangerous corn aflatoxin.

The spiraling use of corn for food and fuel is creating heightened concerns about contamination of this staple crop with deadly aflatoxin. Produced by certain fungi that grow on corn, this contaminant is a known human carcinogen that especially threatens food safety in the developing world and can potentially cause the loss of hundreds of millions of dollars in the United States each year.

Dr. Bruce Hammond, a lead researcher at Monsanto’s Product Safety Center, says that aflatoxin is a potent liver carcinogen and source of other health concerns in humans and animals. Tightly regulated by the Food and Drug Administration (FDA), Hammond says threatening levels of the contaminant are kept out of the U.S. food supply. But in Africa and the developing world, poor regulation has made aflatoxin a significant food safety issue. Growing conditions in Africa are well-suited for Aspergillus flavus, the fungus that produces aflatoxin, and children are the most susceptible.

At the 235th national meeting of the American Chemical Society in New Orleans recently, Hammond and others presented advances towards the production of corn less susceptible to aflatoxin contamination. The new varieties could contribute to the reduction of the worldwide threat of the deadly toxin, improve food quality in developing countries, and increase corn yield for food and in the U.S.

In Africa, where both animals and man eat feed corn, people die as a result of acute aflatoxin exposure. In 2007, there were over a hundred deaths in Kenya alone. Levels of the liver toxin rise to especially dangerous levels in those with hepatitis.

“There are studies documenting the correlation between growth issues in West African children and ingestion of aflatoxins,” said Robert L. Brown, a plant pathologist at the United States Department of Agriculture who studies genes that might confer aflatoxin resistance in corn. He also said the toxin has an effect on immune function in children. Brown is in the process of releasing six new corn inbred lines that are the result of crosses between U.S. aflatoxin-resistant lines and African resistant lines. These new inbreds have been selected for valued crop characteristics as well as for resistance.

Estimates suggest that 4.5 billion people in developing countries are chronically exposed to aflatoxin. While the health threat looms in developing nations, it is also a significant economic threat to agriculture in the U.S.

“Because of climate, you can find an aflatoxin breakout somewhere in the southern U.S. pretty much every year,” says Robert L. Brown, a USDA plant pathologist. These outbreaks can drive up prices for ethanol if its feed corn byproducts become contaminated.

In the quest to engineer better corn crops, scientists at Monsanto are targeting insect pests that can rob corn yield and decrease grain quality. The first generation of Bt (Bacillus thuringiensis) corn suffers less fungal infection and has lower levels of certain mycotoxins, but not aflatoxin. Hammond’s team followed up on these observations with the aim to reduce aflatoxin levels.

Today, Monsanto researchers aim to confer even more insect protection to the second generation of Bt corn. Pending regulatory approval, the new varieties could include additional genes that guard against a broader variety of pests like the fall armyworm, a particular threat to the southern United States associated with aflatoxin contamination.

Preliminary trials found that the new Bt corn variety had reduced levels of aflatoxin, says Hammond. Other sites in the U.S. and in Argentina also showed lower insect damage to the corn from other pests.

“These preliminary results are encouraging, and we look forward to more trials performed under a variety of environmental conditions to show that these reductions are reproducible,” says Hammond.

The researcher’s future efforts aim to lessen the effect of other environmental stressors that can trigger fungal growth in plants.

“If we take insect protection, combine it with drought tolerance, protect the roots against root damage, have herbicide resistance, and improved nitrogen utilization all in the same plant, maybe we will have plants that are much less susceptible to these stress factors and, as a secondary effect, reduced mycotoxin contamination,” says Hammond.

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